| Name | BIBU 1361 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2981 |
| Prices | $105.00, $225.00 |
| Sizes | 1 mg, 10 mg |
| Function Type | Inhibitor |
| Cas Number | 793726-84-8 |
| Chemical Name | N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride |
| Formula | C22H27ClFN7.2HCl |
| Molecular Weight | 516.87 |
| Purity | >97 % |
| Description | Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μ M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice. |
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