Bicalutamide

• Supplier: Tocris Bioscience
• Catalog: 2416
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 90357-06-5
• Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
• Formula: C18H14F4N2O4S
• Molecular Weight: 430.37
• Purity: >99 %
• Description: Orally active non-steroidal androgen receptor antagonist (IC 50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo .

Product References

ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. - ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen.

Furr BJ, Valcaccia B, Curry B, Woodburn JR, Chesterson G, Tucker H. J Endocrinol. 1987 Jun;113(3):R7-9.

Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of - Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of

Tucker H, Crook JW, Chesterson GJ. J Med Chem. 1988 May;31(5):954-9.

The preclinical development of bicalutamide: pharmacodynamics and mechanism of - The preclinical development of bicalutamide: pharmacodynamics and mechanism of

Furr BJ, Tucker H. Urology. 1996 Jan;47(1A Suppl):13-25; discussion 29-32.