Bicifadine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3389
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 66504-75-4
• Chemical Name: 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexanehydrochloride
• Formula: C12H15N.HCl
• Molecular Weight: 209.72
• Purity: >98 %
• Description: Potent antagonist of the noradrenalin transporter (IC 50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC 50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain.

Product References

1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. - 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents.

Epstein JW, Brabander HJ, Fanshawe WJ, Hofmann CM, McKenzie TC, Safir SR, Osterberg AC, Cosulich DB, Lovell FM. J Med Chem. 1981 May;24(5):481-90.

Characterization of the antinociceptive actions of bicifadine in models of acute, - Characterization of the antinociceptive actions of bicifadine in models of acute,

Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E. J Pharmacol Exp Ther. 2007 Jun;321(3):1208-25. Epub 2007 Feb 26.