BIIB 021

• Supplier: Tocris Bioscience
• Catalog: 0767
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 848695-25-0
• Chemical Name: 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
• Formula: C14H15ClN6O
• Molecular Weight: 318.76
• Purity: >98 %
• Description: Selective, Hsp90 competitive inhibitor (K i = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na + K + ATPase. Induces degradation of HER-2 in vitro (EC 50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

Product References

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the - BIIB021, an orally available, fully synthetic small-molecule inhibitor of the

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ. Mol Cancer Ther. 2009 Apr;8(4):921-9.

BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell - BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell

Yin X, Zhang H, Lundgren K, Wilson L, Burrows F, Shores CG. Int J Cancer. 2010 Mar 1;126(5):1216-25.