BIIE 0246

Name BIIE 0246
Supplier Tocris Bioscience
Catalog 4608
Prices $145.00, $309.00
Sizes 1 mg, 10 mg
Function Type Antagonist
Cas Number 246146-55-4
Chemical Name N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide
Formula C49H57N11O6
Molecular Weight 896.06
Purity >98 %
Description Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y 2 receptor (IC 50 = 15 nM). Displays > 650-fold selectivity over Y 1 , Y 4 and Y 5 receptors. Active in vivo .
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Product References

BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist. - BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist.

Doods H, Gaida W, Wieland HA, Dollinger H, Schnorrenberg G, Esser F, Engel W, Eberlein W, Rudolf K. Eur J Pharmacol. 1999 Nov 19;384(2-3):R3-5.

BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor - BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor

Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R. Br J Pharmacol. 2000 Mar;129(6):1075-88.

Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y - Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y

Malmstrom RE. Br J Pharmacol. 2001 Aug;133(7):1073-80.