BIM 23056

• Supplier: Tocris Bioscience
• Catalog: 2842
• Prices: $225.00
• Sizes: 1 mg
• Cas Number: 150155-61-6
• Formula: C71H81N11O9
• Molecular Weight: 1232.49
• Description: Somatostatin receptor ligand (K i values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst 1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [ 35 S]-GTP γ S binding at sst 3 and sst 5 receptors (PK B values are 6.33 and 5.84 respectively).

Product References

Cloned somatostatin receptors: identification of subtype-selective peptides and - Cloned somatostatin receptors: identification of subtype-selective peptides and

Raynor K, Murphy WA, Coy DH, Taylor JE, Moreau JP, Yasuda K, Bell GI, Reisine T. Mol Pharmacol. 1993 Jun;43(6):838-44.

Subtype selectivity of peptide analogs for all five cloned human somatostatin - Subtype selectivity of peptide analogs for all five cloned human somatostatin

Patel YC, Srikant CB. Endocrinology. 1994 Dec;135(6):2814-7.

Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 - Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5

Wilkinson GF, Thurlow RJ, Sellers LA, Coote JE, Feniuk W, Humphrey PP. Br J Pharmacol. 1996 Jun;118(3):445-7.

Characterisation of human recombinant somatostatin receptors. 2. Modulation of - Characterisation of human recombinant somatostatin receptors. 2. Modulation of

Siehler S, Hoyer D. Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):500-9.