BINA

• Supplier: Tocris Bioscience
• Catalog: 4374
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 866823-73-6
• Chemical Name: 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylicacid
• Formula: C30H30O4
• Molecular Weight: 454.56
• Purity: >98 %
• Description: Selective positive allosteric modulator of mGlu 2 (EC 50 = 33.2 nM in CHO cells expressing human mGlu 2 ). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

Product References

Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype - Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype

Bonnefous C, Vernier JM, Hutchinson JH, Gardner MF, Cramer M, James JK, Rowe BA, Daggett LP, Schaffhauser H, Kamenecka TM. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4354-8.

Biphenyl-indanone A, a positive allosteric modulator of the metabotropic - Biphenyl-indanone A, a positive allosteric modulator of the metabotropic

Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, de Paulis T, Conn PJ. J Pharmacol Exp Ther. 2006 Jul;318(1):173-85. Epub 2006 Apr 11.

A selective positive allosteric modulator of metabotropic glutamate receptor - A selective positive allosteric modulator of metabotropic glutamate receptor

Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E. Mol Pharmacol. 2007 Aug;72(2):477-84. Epub 2007 May 25.