BIO

• Supplier: Tocris Bioscience
• Catalog: 0347
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 667463-62-9
• Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-oxime
• Formula: C16H10BrN3O2
• Molecular Weight: 356.17
• Purity: >98 %
• Description: Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC 50 values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro ; also promotes proliferation and dedifferentiation in cardiomyocytes. Negative control available (Cat. No. 3873).

Product References

GSK-3-selective inhibitors derived from Tyrian purple indirubins. - GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. Chem Biol. 2003 Dec;10(12):1255-66.

Structural basis for the synthesis of indirubins as potent and selective - Structural basis for the synthesis of indirubins as potent and selective

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. J Med Chem. 2004 Feb 12;47(4):935-46.

The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. - The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes.

Tseng AS, Engel FB, Keating MT. Chem Biol. 2006 Sep;13(9):957-63.