BIO 1211

• Supplier: Tocris Bioscience
• Catalog: 3194
• Prices: $159.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 187735-94-0
• Formula: C36H48N6O9
• Molecular Weight: 708.8
• Description: Selective, high affinity α 4 β 1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α 4 β 1 (K D = 70 pM; IC 50 = 0.004 μ M). Selective for α 4 β 1 over a range of other integrins (IC 50 >100 μ M for α 1 β 1 , α 5 β 1 and α 6 β 1 ).

Product References

Multiple activation states of integrin alpha4beta1 detected through their - Multiple activation states of integrin alpha4beta1 detected through their

Chen LL, Whitty A, Lobb RR, Adams SP, Pepinsky RB. J Biol Chem. 1999 May 7;274(19):13167-75.

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic - Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic

Lin Kc, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, Lee WC, Hammond CE, Kalkunte S, Chen LL, Pepinsky RB, Leone DR, Sprague AG, Abraham WM, Gill A, Lobb RR, Adams SP. J Med Chem. 1999 Mar 11;42(5):920-34.

Discovery of - Discovery of

Muro F, Iimura S, Sugimoto Y, Yoneda Y, Chiba J, Watanabe T, Setoguchi M, Iigou Y, Matsumoto K, Satoh A, Takayama G, Taira T, Yokoyama M, Takashi T, Nakayama A, Machinaga N. J Med Chem. 2009 Dec 24;52(24):7974-92.