BIO-acetoxime

• Supplier: Tocris Bioscience
• Catalog: 5051
• Prices: $129.00, $279.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 667463-85-6
• Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
• Formula: C18H12BrN3O3
• Molecular Weight: 398.21
• Purity: >98 %
• Description: Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Product References

GSK-3-selective inhibitors derived from Tyrian purple indirubins. - GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. Chem Biol. 2003 Dec;10(12):1255-66.

Structural basis for the synthesis of indirubins as potent and selective - Structural basis for the synthesis of indirubins as potent and selective

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. J Med Chem. 2004 Feb 12;47(4):935-46.

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory - Wnt signaling arrests effector T cell differentiation and generates CD8+ memory

Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP. Nat Med. 2009 Jul;15(7):808-13.