Bisindolylmaleimide II

• Supplier: Tocris Bioscience
• Catalog: 0918
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 137592-45-1
• Chemical Name: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
• Formula: C27H26N4O2
• Molecular Weight: 438.52
• Purity: >97 %
• Description: Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC 50 = 0.01 μ M). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC 50 values are 0.75 and 2 μ M for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC 50 ~ 0.03 μ M for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

Product References

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein - The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein

Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, et al.. J Biol Chem. 1991 Aug 25;266(24):15771-81.

Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit - Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit

Mahata M, Mahapatra NR, O'Connor DT, Mahata SK. Mol Pharmacol. 2002 Jun;61(6):1340-7.