BIX 01294

• Supplier: Tocris Bioscience
• Catalog: 5375
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1392399-03-9
• Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride
• Formula: C28H38N6O2.3HCl
• Molecular Weight: 600.02
• Purity: >98 %
• Description: GLP and G9a histone lysine methyltransferase inhibitor (IC 50 values are 0.7 and 1.7 μ M respectively) that displays no activity at other histone methyltransferases up to 37 μ M. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro .

Product References

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone - Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone

Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, Rea S, Mechtler K, Kowalski JA, Homon CA, Kelly TA, Jenuwein T. Mol Cell. 2007 Feb 9;25(3):473-81.

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and - Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and

Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Cell Stem Cell. 2008 Nov 6;3(5):568-74.

Structural basis for G9a-like protein lysine methyltransferase inhibition by - Structural basis for G9a-like protein lysine methyltransferase inhibition by

Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Nat Struct Mol Biol. 2009 Mar;16(3):312-7.

Small-molecule histone methyltransferase inhibitors display rapid antimalarial - Small-molecule histone methyltransferase inhibitors display rapid antimalarial

Malmquist NA, Moss TA, Mecheri S, Scherf A, Fuchter MJ. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. doi: