| Name | BIX 02189 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3364 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1265916-41-3 |
| Chemical Name | (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide |
| Formula | C27H28N4O2 |
| Molecular Weight | 440.54 |
| Purity | >98 % |
| Description | Selective MEK5 and ERK5 inhibitor (IC 50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells. |
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