| Name | BIX NHE1 inhibitor |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4842 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1204329-34-9 |
| Chemical Name | 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamidehydrochloride |
| Formula | C16H19F3N4O2.HCl |
| Molecular Weight | 392.8 |
| Purity | >98 % |
| Description | Potent and selective NHE1 inhibitor (IC 50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo . Prevents phenylephrine -induced cardiomyocyte hypertrophy in vitro , and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable. |
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Tertyshnikova S, Knox RJ, Plym MJ, Thalody G, Griffin C, Neelands T, Harden DG, Signor L, Weaver D, Myers RA, Lodge NJ. J Pharmacol Exp Ther. 2005 Apr;313(1):250-9. Epub 2004 Dec 17.
Gonczi M, Szentandrassy N, Johnson IT, Heagerty AM, Weston AH. Br J Pharmacol. 2006 Mar;147(5):496-505.