| Name | ( S )-(-)-Blebbistatin |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5502 |
| Prices | $175.00 |
| Sizes | 1 mg |
| Function Type | Inhibitor |
| Cas Number | 856925-71-8 |
| Chemical Name | (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one |
| Formula | C18H16N2O2 |
| Molecular Weight | 292.34 |
| Purity | >99 % |
| Description | Selective inhibitor of myosin II ATPase activity (IC 50 ~0.5 - 5 μ M); active enantiomer of (±)-blebbistatin (Cat. No. 1760). Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. |
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Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, Mitchison TJ. Science. 2003 Mar 14;299(5613):1743-7.
Limouze J, Straight AF, Mitchison T, Sellers JR. J Muscle Res Cell Motil. 2004;25(4-5):337-41.