(±)-Blebbistatin

• Supplier: Tocris Bioscience
• Catalog: 1853
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 674289-55-5
• Chemical Name: (±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
• Formula: C18H16N2O2
• Molecular Weight: 292.34
• Purity: >98 %
• Description: Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Product References

Dissecting temporal and spatial control of cytokinesis with a myosin II - Dissecting temporal and spatial control of cytokinesis with a myosin II

Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, Mitchison TJ. Science. 2003 Mar 14;299(5613):1743-7.

Specificity of blebbistatin, an inhibitor of myosin II. - Specificity of blebbistatin, an inhibitor of myosin II.

Limouze J, Straight AF, Mitchison T, Sellers JR. J Muscle Res Cell Motil. 2004;25(4-5):337-41.

Non-muscle myosin II regulates survival threshold of pluripotent stem cells. - Non-muscle myosin II regulates survival threshold of pluripotent stem cells.

Walker A, Su H, Conti MA, Harb N, Adelstein RS, Sato N. Nat Commun. 2010 Sep 7;1:71.