BMH 21

• Supplier: Tocris Bioscience
• Catalog: 2538
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 896705-16-1
• Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
• Formula: C21H20N4O2
• Molecular Weight: 360.41
• Purity: >98 %
• Description: p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Product References

Identification of novel p53 pathway activating small-molecule compounds reveals - Identification of novel p53 pathway activating small-molecule compounds reveals

Peltonen K, Colis L, Liu H, Jaamaa S, Moore HM, Enback J, Laakkonen P, Vaahtokari A, Jones RJ, af Hallstrom TM, Laiho M. PLoS One. 2010 Sep 27;5(9):e12996.

Design, synthesis, and structure-activity relationships of - Design, synthesis, and structure-activity relationships of

Colis L, Ernst G, Sanders S, Liu H, Sirajuddin P, Peltonen K, DePasquale M, Barrow JC, Laiho M. J Med Chem. 2014 Jun 12;57(11):4950-61.

A targeting modality for destruction of RNA polymerase I that possesses - A targeting modality for destruction of RNA polymerase I that possesses

Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, Bai B, Rudek MA, Bieberich CJ, Laiho M. Cancer Cell. 2014 Jan 13;25(1):77-90.