BMS 182874 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1383
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1215703-04-0
• Chemical Name: 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamidehydrochloride
• Formula: C17H19N3O3S.HCl
• Molecular Weight: 381.88
• Purity: >98 %
• Description: Potent, selective and competitive non-peptide endothelin ET A receptor antagonist (K i = 48 nM). Displays > 1000-fold selectivity over ET B receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo . Inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro .

Product References

The discovery of sulfonamide endothelin antagonists and the development of the - The discovery of sulfonamide endothelin antagonists and the development of the

Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KE, Mitchell C, Liu EC, Webb ML, Murugesan N, Dickey J, et al.. J Med Chem. 1994 Feb 4;37(3):329-31.

BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist. - BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist.

Webb ML, Bird JE, Liu EC, Rose PM, Serafino R, Stein PD, Moreland S. J Pharmacol Exp Ther. 1995 Mar;272(3):1124-34.

Pharmacological characterization of endothelin receptors-mediated contraction in - Pharmacological characterization of endothelin receptors-mediated contraction in

Khan H, Naylor RJ, Tuladhar BR. Br J Pharmacol. 2006 Mar;147(6):607-11.