| Name | BMS 193885 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2665 |
| Prices | $235.00, $965.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 679839-66-8 |
| Chemical Name | 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylicacid3,5-dimethylesterL-Lactate |
| Formula | C33H42N4O6.C3H6O3 |
| Molecular Weight | 680.79 |
| Purity | >99 % |
| Description | Potent, competitive neuropeptide (NPY) Y 1 antagonist (K i = 3.3 nM, IC 50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ 1 , α 1 , Y 2 , Y 4 and Y 5 receptors respectively. Reduces food intake and body weight via central Y 1 inhibition and is brain penetrant. |
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Poindexter GS, Bruce MA, Breitenbucher JG, Higgins MA, Sit SY, Romine JL, Martin SW, Ward SA, McGovern RT, Clarke W, Russell J, Antal-Zimanyi I. Bioorg Med Chem. 2004 Jan 15;12(2):507-21.
Antal-Zimanyi I, Bruce MA, Leboulluec KL, Iben LG, Mattson GK, McGovern RT, Hogan JB, Leahy CL, Flowers SC, Stanley JA, Ortiz AA, Poindexter GS. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.