BMS 195614

• Supplier: Tocris Bioscience
• Catalog: 3242
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 253310-42-8
• Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoicacid
• Formula: C29H24N2O3
• Molecular Weight: 448.51
• Purity: >98 %
• Description: Neutral retinoic acid receptor (RAR) α -selective antagonist (K i = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

Product References

Structural basis for engineering of retinoic acid receptor isotype-selective - Structural basis for engineering of retinoic acid receptor isotype-selective

Gehin M, Vivat V, Wurtz JM, Losson R, Chambon P, Moras D, Gronemeyer H. Chem Biol. 1999 Aug;6(8):519-29.

Differential action on coregulator interaction defines inverse retinoid agonists - Differential action on coregulator interaction defines inverse retinoid agonists

Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H. Chem Biol. 2009 May 29;16(5):479-89.