BMS 265246

• Supplier: Tocris Bioscience
• Catalog: 3660
• Prices: $175.00, $735.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 582315-72-8
• Chemical Name: (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone
• Formula: C18H17F2N3O2
• Molecular Weight: 345.34
• Purity: >97 %
• Description: Potent cdk1/2 inhibitor (IC 50 values are 6, 9 and 230 nM for cdk1, cdk2 and cdk4, respectively). Inhibits proliferation of HCT-116 colon cancer cells in vitro .

Product References

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase - Reductions in beta-amyloid concentrations in vivo by the gamma-secretase

Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. Biochem Pharmacol. 2005 Feb 15;69(4):689-98. Epub 2005 Jan 7.

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma - Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma

Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM. J Pharmacol Exp Ther. 2005 Feb;312(2):635-43. Epub 2004 Sep 27.

Ex vivo occupancy of gamma-secretase inhibitors correlates with brain - Ex vivo occupancy of gamma-secretase inhibitors correlates with brain

Goldstein ME, Cao Y, Fiedler T, Toyn J, Iben L, Barten DM, Pierdomenico M, Corsa J, Prasad CV, Olson RE, Li YW, Zaczek R, Albright CF. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8. Epub 2007 Jul 19.