| Name | BMS 303141 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2870 |
| Prices | $179.00, $745.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 943962-47-8 |
| Chemical Name | 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide |
| Formula | C19H15Cl2NO4S |
| Molecular Weight | 424.3 |
| Purity | >99 % |
| Description | ATP citrate lyase (ACL) inhibitor (IC 50 = 0.13 μ M for human recombinant ACL); blocks lipid synthesis (IC 50 = 8 μ M in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μ M. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable. |
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Li JJ, Wang H, Tino JA, Robl JA, Herpin TF, Lawrence RM, Biller S, Jamil H, Ponticiello R, Chen L, Chu CH, Flynn N, Cheng D, Zhao R, Chen B, Schnur D, Obermeier MT, Sasseville V, Padmanabha R, Pike K, Harrity T. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11. Epub 2007 Mar 12.
Ma Z, Chu CH, Cheng D. J Lipid Res. 2009 Oct;50(10):2131-5.