BMS 309403

• Supplier: Tocris Bioscience
• Catalog: 4609
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 300657-03-8
• Chemical Name: 2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-aceticacid
• Formula: C31H26N2O3
• Molecular Weight: 474.55
• Purity: >98 %
• Description: Potent and selective fatty acid binding protein 4, adipocyte (FABP4) inhibitor (K i values are <2, 250 and 350 nM for FABP4, FABP3 and FABP5 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.

Product References

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding - Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding

Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Nature. 2007 Jun 21;447(7147):959-65. Epub 2007 Jun 6.

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding - Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding

Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL, Sheriff S, Adam LP, Ewing WR, Robl JA. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5. Epub 2006 Dec 21.

BMS309403 stimulates glucose uptake in myotubes through activation of - BMS309403 stimulates glucose uptake in myotubes through activation of

Lin W, Huang X, Zhang L, Chen D, Wang D, Peng Q, Xu L, Li J, Liu X, Li K, Ding K, Jin S, Li J, Wu D. PLoS One. 2012;7(8):e44570.