BMS 345541

• Supplier: Tocris Bioscience
• Catalog: 5258
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 547757-23-3
• Chemical Name: N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediaminehydrochloride
• Formula: C14H17N5.HCl
• Molecular Weight: 291.78
• Purity: >99 %
• Description: Selective allosteric inhibitor of IKK (IC 50 values are 0.3 and 4.0 μ M for IKK β and IKK α respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NF κ B dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Product References

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an - BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an

Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, Yang X, Iotzova VS, Clarke W, Strnad J, Qiu Y, Zusi FC. J Biol Chem. 2003 Jan 17;278(3):1450-6. Epub 2002 Oct 25.

Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage - Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage

Pattoli MA, MacMaster JF, Gregor KR, Burke JR. J Pharmacol Exp Ther. 2005 Oct;315(1):382-8. Epub 2005 Jul 11.

Inhibition of choriodecidual cytokine production and inflammatory gene expression - Inhibition of choriodecidual cytokine production and inflammatory gene expression

De Silva D, Mitchell MD, Keelan JA. Br J Pharmacol. 2010 Aug;160(7):1808-22.