BMS 470539 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3409
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 457893-92-4
• Chemical Name: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanonedihydrochloride
• Formula: C32H41N5O4.2HCl
• Molecular Weight: 632.62
• Purity: >98 %
• Description: Potent, selective melanocortin MC 1 receptor agonist (IC 50 = 120 nM). Exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. Inhibits leukocyte trafficking.

Product References

Discovery of tyrosine-based potent and selective melanocortin-1 receptor - Discovery of tyrosine-based potent and selective melanocortin-1 receptor

Herpin TF, Yu G, Carlson KE, Morton GC, Wu X, Kang L, Tuerdi H, Khanna A, Tokarski JS, Lawrence RM, Macor JE. J Med Chem. 2003 Mar 27;46(7):1123-6.

A selective small molecule agonist of the melanocortin-1 receptor inhibits - A selective small molecule agonist of the melanocortin-1 receptor inhibits

Kang L, McIntyre KW, Gillooly KM, Yang Y, Haycock J, Roberts S, Khanna A, Herpin TF, Yu G, Wu X, Morton GC, Tuerdi H, Koplowitz B, Walker SG, Wardwell-Swanson J, Macor JE, Lawrence RM, Carlson KE. J Leukoc Biol. 2006 Oct;80(4):897-904. Epub 2006 Aug 3.

The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking - The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking

Leoni G, Voisin MB, Carlson K, Getting S, Nourshargh S, Perretti M. Br J Pharmacol. 2010 May;160(1):171-80.