BMS 493

• Supplier: Tocris Bioscience
• Catalog: 4053
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 215030-90-3
• Chemical Name: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
• Formula: C29H24O2
• Molecular Weight: 404.5
• Purity: >98 %
• Description: Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RAR α , RAR β and RAR γ ).

Product References

Systemic bud induction and retinoic acid signaling underlie whole body - Systemic bud induction and retinoic acid signaling underlie whole body

Rinkevich Y, Paz G, Rinkevich B, Reshef R. PLoS Biol. 2007 Apr;5(4):e71.

Differential action on coregulator interaction defines inverse retinoid agonists - Differential action on coregulator interaction defines inverse retinoid agonists

Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H. Chem Biol. 2009 May 29;16(5):479-89.