| Name | BMS 599626 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5492 |
| Prices | $289.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Chemical Name | (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamatedihydrochloride |
| Formula | C27H27FN8O3.2HCl |
| Molecular Weight | 603.48 |
| Purity | >98 % |
| Description | Potent and selective EGFR and ErbB2 inhibitor (IC 50 values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC 50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo . Orally bioavailable. |
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Wong TW, Lee FY, Yu C, Luo FR, Oppenheimer S, Zhang H, Smykla RA, Mastalerz H, Fink BE, Hunt JT, Gavai AV, Vite GD. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
Gavai AV, Fink BE, Fairfax DJ, Martin GS, Rossiter LM, Holst CL, Kim SH, Leavitt KJ, Mastalerz H, Han WC, Norris D, Goyal B, Swaminathan S, Patel B, Mathur A, Vyas DM, Tokarski JS, Yu C, Oppenheimer S, Zhang H, Marathe P, Fargnoli J, Lee FY, Wong TW, Vite GD. J Med Chem. 2009 Nov 12;52(21):6527-30.