BMS 986187

Name BMS 986187
Supplier Tocris Bioscience
Catalog 3410
Prices $175.00, $735.00
Sizes 10 mg, 50 mg
Function Type Modulator
Cas Number 684238-37-7
Chemical Name 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
Formula C31H34O4
Molecular Weight 470.61
Purity >98 %
Description Potent δ -opioid receptor positive allosteric modulator (EC 50 = 30 nM). Exhibits 100-fold selectivity for δ over μ -opioid receptor. Enhances affinity of [Leu 5 ]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ -opioid receptor.
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Product References

Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 - Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2

Cherney RJ, Mo R, Meyer DT, Nelson DJ, Lo YC, Yang G, Scherle PA, Mandlekar S, Wasserman ZR, Jezak H, Solomon KA, Tebben AJ, Carter PH, Decicco CP. J Med Chem. 2008 Feb 28;51(4):721-4.

CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. - CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels.

You H, Altier C, Zamponi GW. Mol Pharmacol. 2010 Feb;77(2):211-7.