BMY 14802 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3129
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 105565-55-7
• Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanolhydrochloride
• Formula: C18H22F2N4O.HCl
• Molecular Weight: 384.86
• Purity: >98 %
• Description: Potent sigma receptor antagonist (IC 50 = 112 nM) with modest to weak affinity for 5-HT 1A and α 1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

Product References

Synthesis and biological characterization of - Synthesis and biological characterization of

Yevich JP, New JS, Lobeck WG, Dextraze P, Bernstein E, Taylor DP, Yocca FD, Eison MS, Temple DL Jr. J Med Chem. 1992 Nov 27;35(24):4516-25.

A role for sigma binding in the antipsychotic profile of BMY 14802? - A role for sigma binding in the antipsychotic profile of BMY 14802?

Taylor DP, Eison MS, Moon SL, Schlemmer RF Jr, Shukla UA, VanderMaelen CP, Yocca FD, Gallant DJ, Behling SH, Boissard CG, et al.. NIDA Res Monogr. 1993;133:125-57.

Further characterization of the effects of BMY 14802 on dopamine neuronal - Further characterization of the effects of BMY 14802 on dopamine neuronal

Zhang J, Chiodo LA, Freeman AS. Synapse. 1993 Dec;15(4):276-84.