BMY 7378 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1442
• Prices: $69.00, $295.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 21102-95-4
• Chemical Name: 8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dionedihydrochloride
• Formula: C22H31N3O3.2HCl
• Molecular Weight: 458.42
• Description: 5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ .

Product References

Further investigation of the in vivo pharmacological properties of the putative - Further investigation of the in vivo pharmacological properties of the putative

Sharp T, Backus LI, Hjorth S, Bramwell SR, Grahame-Smith DG. Eur J Pharmacol. 1990 Feb 13;176(3):331-40.

The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial - The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial

Greuel JM, Glaser T. Eur J Pharmacol. 1992 Feb 11;211(2):211-9.

The specific contribution of the novel alpha-1D adrenoceptor to the contraction - The specific contribution of the novel alpha-1D adrenoceptor to the contraction

Piascik MT, Guarino RD, Smith MS, Soltis EE, Saussy DL Jr, Perez DM. J Pharmacol Exp Ther. 1995 Dec;275(3):1583-9.

Pharmacological evidence for alpha(1D)-adrenoceptors in the rabbit ventricular - Pharmacological evidence for alpha(1D)-adrenoceptors in the rabbit ventricular

Yang HT, Endoh M. Br J Pharmacol. 1997 Dec;122(8):1541-50.