Borrelidin

• Supplier: Tocris Bioscience
• Catalog: 3177
• Prices: $379.00
• Sizes: 1 mg
• Cas Number: 7184-60-3
• Chemical Name: (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylicacid
• Formula: C28H43NO6
• Molecular Weight: 489.64
• Purity: >98 %
• Description: Antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC 50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.

Product References

Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary - Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary

Wakabayashi T, Kageyama R, Naruse N, Tsukahara N, Funahashi Y, Kitoh K, Watanabe Y. J Antibiot (Tokyo). 1997 Aug;50(8):671-6.

Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: - Anti-angiogenesis effects of borrelidin are mediated through distinct pathways:

Kawamura T, Liu D, Towle MJ, Kageyama R, Tsukahara N, Wakabayashi T, Littlefield BA. J Antibiot (Tokyo). 2003 Aug;56(8):709-15.

Borrelidin modulates the alternative splicing of VEGF in favour of - Borrelidin modulates the alternative splicing of VEGF in favour of

Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, Bates DO, Wilkinson B. Chem Sci. 2011 Feb 1;2011(2):273-278.