Bosentan

• Supplier: Tocris Bioscience
• Catalog: 4706
• Prices: $65.00, $275.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 147536-97-8
• Chemical Name: 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide
• Formula: C27H29N5O6S
• Molecular Weight: 551.61
• Purity: >98 %
• Description: High affinity dual ET A and ET B receptor antagonist (K i values are 4.7 and 95 nM for ET A and ET B , respectively). Inhibits ET-1 induced contraction of isolated rat aorta and sarafotoxin S6C-induced contraction of rat trachea in vitro . Orally bioavailable.

Product References

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of - Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of

Boschelli DH, Ye F, Wang YD, Dutia M, Johnson SL, Wu B, Miller K, Powell DW, Yaczko D, Young M, Tischler M, Arndt K, Discafani C, Etienne C, Gibbons J, Grod J, Lucas J, Weber JM, Boschelli F. J Med Chem. 2001 Nov 8;44(23):3965-77.

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl - SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl

Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, Frost P, Ye F, Boschelli DH, Boschelli F. Cancer Res. 2003 Jan 15;63(2):375-81.

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft - SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft

Golas JM, Lucas J, Etienne C, Golas J, Discafani C, Sridharan L, Boghaert E, Arndt K, Ye F, Boschelli DH, Li F, Titsch C, Huselton C, Chaudhary I, Boschelli F. Cancer Res. 2005 Jun 15;65(12):5358-64.

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and - SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and

Vultur A, Buettner R, Kowolik C, Liang W, Smith D, Boschelli F, Jove R. Mol Cancer Ther. 2008 May;7(5):1185-94.