bPiDDB

• Supplier: Tocris Bioscience
• Catalog: 0556
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 525596-66-1
• Chemical Name: 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium]dibromide
• Formula: C24H38Br2N2
• Molecular Weight: 514.38
• Purity: >98 %
• Description: Orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC 50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μ M at α 3 β 4, α 1 β 1 ε δ , α 3 β 4 β 3, α 6 β 4 β 3, α 7, α 4 β 2, α 3 β 2 β 3 and α 6/3 β 2 β 3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC 50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.

Product References

N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition - N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition

Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. J Pharmacol Exp Ther. 2008 Aug;326(2):563-76.

Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on - Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on

Rahman S, Zhang Z, Papke RL, Crooks PA, Dwoskin LP, Bardo MT. Br J Pharmacol. 2008 Feb;153(4):792-804. Epub 2007 Dec 3.