BQ-123

• Supplier: Tocris Bioscience
• Catalog: 1500
• Prices: $175.00
• Sizes: 500 µg
• Function Type: Antagonist
• Cas Number: 136553-81-6
• Formula: C31H42N6O7
• Molecular Weight: 611
• Description: Selective ET A endothelin receptor antagonist (K i values are 1.4 and 1500 nM at ET A and ET B receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.

Product References

Distinct subdomains of human endothelin receptors determine their selectivity to - Distinct subdomains of human endothelin receptors determine their selectivity to

Sakamoto A, Yanagisawa M, Sawamura T, Enoki T, Ohtani T, Sakurai T, Nakao K, Toyo-oka T, Masaki T. J Biol Chem. 1993 Apr 25;268(12):8547-53.

Effects of selective ETB-receptor stimulation on arterial, venous and capillary - Effects of selective ETB-receptor stimulation on arterial, venous and capillary

Ekelund U, Adner M, Edvinsson L, Mellander S. Br J Pharmacol. 1994 Jul;112(3):887-94.

Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on - Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on

Makatani M, Fujitani Y, Takimoto M, Oda K, Sasaki Y, Hori S, Inui T, Sakaki J, Okada T, Hoshiko K, Yamamura T. Eur J Pharmacol. 2000 Oct 6;406(1):139-47.

Role of endothelin in cardiovascular disease. - Role of endothelin in cardiovascular disease.

Agapitov AV, Haynes WG. J Renin Angiotensin Aldosterone Syst. 2002 Mar;3(1):1-15.