Sar-[D-Phe 8 ]-des-Arg 9 -Bradykinin

Name Sar-[D-Phe 8 ]-des-Arg 9 -Bradykinin
Supplier Tocris Bioscience
Catalog 3004
Prices $199.00
Sizes 1 mg
Function Type Agonist
Cas Number 126959-88-4
Formula C47H66N12O11
Molecular Weight 975.11
Description Potent and selective bradykinin B 1 receptor agonist (EC 50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo .
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Product References

Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected - Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected

Drapeau G, deBlois D, Marceau F. J Pharmacol Exp Ther. 1991 Dec;259(3):997-1003.

Development and in vivo evaluation of metabolically resistant antagonists of B1 - Development and in vivo evaluation of metabolically resistant antagonists of B1

Drapeau G, Audet R, Levesque L, Godin D, Marceau F. J Pharmacol Exp Ther. 1993 Jul;266(1):192-9.

International union of pharmacology. XLV. Classification of the kinin receptor - International union of pharmacology. XLV. Classification of the kinin receptor

Leeb-Lundberg LM, Marceau F, Muller-Esterl W, Pettibone DJ, Zuraw BL. Pharmacol Rev. 2005 Mar;57(1):27-77.