BRD 4354

• Supplier: Tocris Bioscience
• Catalog: 3522
• Prices: $159.00, $669.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 315698-07-8
• Chemical Name: 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol
• Formula: C21H23ClN4O
• Molecular Weight: 382.89
• Purity: >98 %
• Description: HDAC5 and HDAC9 inhibitor (IC 50 values are 0.85 and 1.88 μ M, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC 50 values are 3.88 - 13.8 μ M). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.

Product References

Niche-based screening identifies small-molecule inhibitors of leukemia stem - Niche-based screening identifies small-molecule inhibitors of leukemia stem

Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Jaras M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MA, Scadden DT, Schreiber SL, Ebert BL, Golub TR. Nat Chem Biol. 2013 Dec;9(12):840-8.