Brefeldin A

Name Brefeldin A
Supplier Tocris Bioscience
Catalog 5454
Prices $139.00
Sizes 5 mg
Function Type Inhibitor
Cas Number 20350-15-6
Chemical Name 1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one
Formula C16H24O4
Molecular Weight 280.36
Purity >98 %
Description Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs).
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Product References

Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G - Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G

Ktistakis NT, Linder ME, Roth MG. Nature. 1992 Mar 26;356(6367):344-6.

Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein - Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein

Tsai SC, Adamik R, Moss J, Vaughan M. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3063-6.

Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP - Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP

Morinaga N, Tsai SC, Moss J, Vaughan M. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12856-60.

Differential effects of endoplasmic reticulum stress-induced autophagy on cell - Differential effects of endoplasmic reticulum stress-induced autophagy on cell

Ding WX, Ni HM, Gao W, Hou YF, Melan MA, Chen X, Stolz DB, Shao ZM, Yin XM. J Biol Chem. 2007 Feb 16;282(7):4702-10. Epub 2006 Nov 29.