BRL 37344, sodium salt

• Supplier: Tocris Bioscience
• Catalog: 1207
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 127299-93-8
• Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyaceticacid,sodiumsalt
• Formula: C19H21NO4ClNa
• Molecular Weight: 385.82
• Purity: >98 %
• Description: Potent and selective β 3 adrenoceptor agonist (K i values are 287, 1750 and 1120 nM for β 3 , β 1 and β 2 receptors respectively). Also available as part of the β -Adrenoceptor Agonist Tocriset™ .

Product References

Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. - Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs.

Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thody VE, Wilson C, Wilson S. Nature. 1984 May 10-16;309(5964):163-5.

The selectivity in vitro of the stereoisomers of the beta-3 adrenoceptor agonist - The selectivity in vitro of the stereoisomers of the beta-3 adrenoceptor agonist

Oriowo MA, Chapman H, Kirkham DM, Sennitt MV, Ruffolo RR Jr, Cawthorne MA. J Pharmacol Exp Ther. 1996 Apr;277(1):22-7.

Function and regulation of the beta 3-adrenoceptor. - Function and regulation of the beta 3-adrenoceptor.

Strosberg AD, Pietri-Rouxel F. Trends Pharmacol Sci. 1996 Oct;17(10):373-81.

BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. - BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro.

Board M, Doyle P, Cawthorne MA. Eur J Pharmacol. 2000 Oct 6;406(1):33-40.