BRL 44408 maleate

• Supplier: Tocris Bioscience
• Catalog: 0948
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 681806-46-2
• Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindolemaleate
• Formula: C13H17N3.C4H4O4
• Molecular Weight: 331.37
• Purity: >98 %
• Description: Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ .

Product References

Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha - Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha

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Subtype-specificity of the presynaptic alpha 2-adrenoceptors modulating - Subtype-specificity of the presynaptic alpha 2-adrenoceptors modulating

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Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the - Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the

Gavin KT, Colgan MP, Moore D, Shanik G, Docherty JR. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):406-11.

Alpha2A- but not alpha2B/C-adrenoceptors modulate noradrenaline release in rat - Alpha2A- but not alpha2B/C-adrenoceptors modulate noradrenaline release in rat

Callado LF, Stamford JA. Eur J Pharmacol. 1999 Jan 29;366(1):35-9.