Bryostatin 1

• Supplier: Tocris Bioscience
• Catalog: 4316
• Prices: $165.00
• Sizes: 10 µg
• Function Type: Activator
• Cas Number: 83314-01-6
• Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoicacidester
• Formula: C47H68O17
• Molecular Weight: 905.04
• Purity: >98 %
• Description: Protein kinase C (PKC) activator that binds with high affinity (K i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Product References

The catalytic domain of protein kinase Cdelta confers protection from - The catalytic domain of protein kinase Cdelta confers protection from

Lorenzo PS, Bogi K, Acs P, Pettit GR, Blumberg PM. J Biol Chem. 1997 Dec 26;272(52):33338-43.

The design, computer modeling, solution structure, and biological evaluation of - The design, computer modeling, solution structure, and biological evaluation of

Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6624-9.

Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. - Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.

Sun MK, Alkon DL. CNS Drug Rev. 2006 Spring;12(1):1-8.

Bryostatin-1 restores hippocampal synapses and spatial learning and memory in - Bryostatin-1 restores hippocampal synapses and spatial learning and memory in

Sun MK, Hongpaisan J, Lim CS, Alkon DL. J Pharmacol Exp Ther. 2014 Jun;349(3):393-401.