Bryostatin 2

• Supplier: Tocris Bioscience
• Catalog: 2383
• Prices: $235.00
• Sizes: 10 µg
• Function Type: Activator
• Cas Number: 87745-28-6
• Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoicacidester
• Formula: C45H66O16
• Molecular Weight: 863
• Purity: >98 %
• Description: Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro . Antitumor.

Product References

Differential effects of bryostatins and phorbol esters on arachidonic acid - Differential effects of bryostatins and phorbol esters on arachidonic acid

Dell'Aquila ML, Herald CL, Kamano Y, Pettit GR, Blumberg PM. Cancer Res. 1988 Jul 1;48(13):3702-8.

Comparison of effects of bryostatins 1 and 2 and - Comparison of effects of bryostatins 1 and 2 and

Dale IL, Bradshaw TD, Gescher A, Pettit GR. Cancer Res. 1989 Jun 15;49(12):3242-5.

Effects of bryostatins 1 and 2 on morphological and functional differentiation of - Effects of bryostatins 1 and 2 on morphological and functional differentiation of

Jalava AM, Heikkila J, Akerlind G, Pettit GR, Akerman KE. Cancer Res. 1990 Jun 1;50(11):3422-8.

Comparison of transcriptional response to phorbol ester, bryostatin 1, and - Comparison of transcriptional response to phorbol ester, bryostatin 1, and

Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Biochem Pharmacol. 2013 Feb 1;85(3):313-24.