Bryostatin 3

Name Bryostatin 3
Supplier Tocris Bioscience
Catalog 5237
Prices $235.00
Sizes 10 µg
Function Type Activator
Cas Number 143370-84-7
Chemical Name (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoicacidester
Formula C46H64O17
Molecular Weight 888.99
Purity >95 %
Description Potent protein kinase C activator (K I = 2.75 nM). Attenuates phorbol 12-myristate 13-acetate (Cat. No. 1201) inhibition of GH4C1 pituitary cell proliferation in vitro .
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Product References

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase - Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase

Wender PA, Cribbs CM, Koehler KF, Sharkey NA, Herald CL, Kamano Y, Pettit GR, Blumberg PM. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7197-201.

Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell - Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell

Mackanos EA, Pettit GR, Ramsdell JS. J Biol Chem. 1991 Jun 15;266(17):11205-12.