BTS 54-505 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1870
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Cas Number: 84484-78-6
• Chemical Name: 1-(4-Chlorophenyl)-α-(2-methylpropyl)cyclobutanemethanaminehydrochloride
• Formula: C15H22NCl.HCl
• Molecular Weight: 288.26
• Purity: >99 %
• Description: Potently active primary amine metabolite of sibutramine (Cat. No. 2290), exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . Reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis in vivo .

Product References

The contribution of metabolites to the rapid and potent down-regulation of rat - The contribution of metabolites to the rapid and potent down-regulation of rat

Luscombe GP, Hopcroft RH, Thomas PC, Buckett WR. Neuropharmacology. 1989 Feb;28(2):129-34.

In vivo criteria to differentiate monoamine reuptake inhibitors from releasing - In vivo criteria to differentiate monoamine reuptake inhibitors from releasing

Gundlah C, Martin KF, Heal DJ, Auerbach SB. J Pharmacol Exp Ther. 1997 Nov;283(2):581-91.

Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major - Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major

Liu YL, Heal DJ, Stock MJ. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1245-53.