Bupropion hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2808
• Prices: $129.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 31677-93-7
• Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanonehydrochloride
• Formula: C13H18ClNO.HCl
• Molecular Weight: 276.2
• Purity: >99 %
• Description: Non-selective inhibitor of dopamine and noradrenalin transporters (K i values are 1.4, 2.8 and 45 μ M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo .

Product References

Bupropion is a nicotinic antagonist. - Bupropion is a nicotinic antagonist.

Slemmer JE, Martin BR, Damaj MI. J Pharmacol Exp Ther. 2000 Oct;295(1):321-7.

Plasma membrane monoamine transporters: structure, regulation and function. - Plasma membrane monoamine transporters: structure, regulation and function.

Torres GE, Gainetdinov RR, Caron MG. Nat Rev Neurosci. 2003 Jan;4(1):13-25.

Review of the pharmacology and clinical profile of bupropion, an antidepressant - Review of the pharmacology and clinical profile of bupropion, an antidepressant

Dwoskin LP, Rauhut AS, King-Pospisil KA, Bardo MT. CNS Drug Rev. 2006 Fall-Winter;12(3-4):178-207.