BX 471

• Supplier: Tocris Bioscience
• Catalog: 5545
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 217645-70-0
• Chemical Name: (2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine
• Formula: C21H24ClFN4O3
• Molecular Weight: 434.89
• Purity: >98 %
• Description: Potent, selective non-peptide CCR1 antagonist (K i = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP- α /CCL3-induced intracellular Ca 2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Product References

Identification and characterization of a potent, selective, and orally active - Identification and characterization of a potent, selective, and orally active

Liang M, Mallari C, Rosser M, Ng HP, May K, Monahan S, Bauman JG, Islam I, Ghannam A, Buckman B, Shaw K, Wei GP, Xu W, Zhao Z, Ho E, Shen J, Oanh H, Subramanyam B, Vergona R, Taub D, Dunning L, Harvey S, Snider RM, Hesselgesser J, Morrissey MM, Perez HD. J Biol Chem. 2000 Jun 23;275(25):19000-8.

A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral - A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral

Anders HJ, Vielhauer V, Frink M, Linde Y, Cohen CD, Blattner SM, Kretzler M, Strutz F, Mack M, Grone HJ, Onuffer J, Horuk R, Nelson PJ, Schlondorff D. J Clin Invest. 2002 Jan;109(2):251-9.

Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal - Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal

Furuichi K, Gao JL, Horuk R, Wada T, Kaneko S, Murphy PM. J Immunol. 2008 Dec 15;181(12):8670-6.