BX 513 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3496
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1216540-18-9
• Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrilehydrochloride
• Formula: C28H29ClN2O.HCl
• Molecular Weight: 481.46
• Purity: >99 %
• Description: Selective CCR1 receptor antagonist (K i values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1 α -induced intracellular calcium mobilization (IC 50 = 2.5 μ M). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.

Product References

Identification and characterization of small molecule functional antagonists of - Identification and characterization of small molecule functional antagonists of

Hesselgesser J, Ng HP, Liang M, Zheng W, May K, Bauman JG, Monahan S, Islam I, Wei GP, Ghannam A, Taub DD, Rosser M, Snider RM, Morrissey MM, Perez HD, Horuk R. J Biol Chem. 1998 Jun 19;273(25):15687-92.

Discovery of novel non-peptide CCR1 receptor antagonists. - Discovery of novel non-peptide CCR1 receptor antagonists.

Ng HP, May K, Bauman JG, Ghannam A, Islam I, Liang M, Horuk R, Hesselgesser J, Snider RM, Perez HD, Morrissey MM. J Med Chem. 1999 Nov 4;42(22):4680-94.

Identification of the first nonpeptidergic inverse agonist for a constitutively - Identification of the first nonpeptidergic inverse agonist for a constitutively

Casarosa P, Menge WM, Minisini R, Otto C, van Heteren J, Jongejan A, Timmerman H, Moepps B, Kirchhoff F, Mertens T, Smit MJ, Leurs R. J Biol Chem. 2003 Feb 14;278(7):5172-8. Epub 2002 Nov 26.