BX 795

• Supplier: Tocris Bioscience
• Catalog: 2769
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 702675-74-9
• Chemical Name: N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
• Formula: C23H26IN7O2S
• Molecular Weight: 591.47
• Purity: >98 %
• Description: Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and I κ B kinase ε (IKK ε ).

Product References

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. - Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Feldman RI, Wu JM, Polokoff MA, Kochanny MJ, Dinter H, Zhu D, Biroc SL, Alicke B, Bryant J, Yuan S, Buckman BO, Lentz D, Ferrer M, Whitlow M, Adler M, Finster S, Chang Z, Arnaiz DO. J Biol Chem. 2005 May 20;280(20):19867-74. Epub 2005 Mar 16.

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES - Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES

Tamguney T, Zhang C, Fiedler D, Shokat K, Stokoe D. Exp Cell Res. 2008 Jul 1;314(11-12):2299-312.

Use of the pharmacological inhibitor BX795 to study the regulation and - Use of the pharmacological inhibitor BX795 to study the regulation and

Clark K, Plater L, Peggie M, Cohen P. J Biol Chem. 2009 May 22;284(21):14136-46.