BYK 49187

• Supplier: Tocris Bioscience
• Catalog: 3734
• Prices: $105.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 163120-31-8
• Chemical Name: 4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one
• Formula: C19H21N5O
• Molecular Weight: 335.4
• Purity: >98 %
• Description: PARP-1 and PARP-2 inhibitor (pIC 50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro ; reduces myocardial infarct size in vivo .

Product References

Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel - Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel

Eltze T, Boer R, Wagner T, Weinbrenner S, McDonald MC, Thiemermann C, Burkle A, Klein T. Mol Pharmacol. 2008 Dec;74(6):1587-98.

5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as - 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as

Sunderland PT, Woon EC, Dhami A, Bergin AB, Mahon MF, Wood PJ, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. J Med Chem. 2011 Apr 14;54(7):2049-59.