Bz 423

• Supplier: Tocris Bioscience
• Catalog: 3735
• Prices: $145.00, $609.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 216691-95-1
• Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
• Formula: C27H21ClN2O2
• Molecular Weight: 440.92
• Purity: >98 %
• Description: ATP synthase inhibitor (IC 50 ~5 μ M). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F 1 F 0 -ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo . Suppresses autoimmunity and prolongs survival in mouse lupus model.

Product References

Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a - Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a

Williams N, Coleman PS. J Biol Chem. 1982 Mar 25;257(6):2834-41.

Pharmacological and molecular characterization of P2X receptors in rat pelvic - Pharmacological and molecular characterization of P2X receptors in rat pelvic

Zhong Y, Dunn PM, Xiang Z, Bo X, Burnstock G. Br J Pharmacol. 1998 Oct;125(4):771-81.

Serum constituents can affect 2'-& 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X(7) - Serum constituents can affect 2'-& 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X(7)

Michel AD, Xing M, Humphrey PP. Br J Pharmacol. 2001 Apr;132(7):1501-8.

Amino acid residues in the P2X7 receptor that mediate differential sensitivity to - Amino acid residues in the P2X7 receptor that mediate differential sensitivity to

Young MT, Pelegrin P, Surprenant A. Mol Pharmacol. 2007 Jan;71(1):92-100. Epub 2006 Oct 10.