CA 074

• Supplier: Tocris Bioscience
• Catalog: 4200
• Prices: $139.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 134448-10-5
• Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
• Formula: C18H29N3O6
• Molecular Weight: 383.44
• Purity: >98 %
• Description: Inhibitor of cathepsin B (K i = 2-5 nM). Displays selectivity over cathepsins H and L (K i = 40-200 μ M). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Product References

Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. - Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.

Towatari T, Nikawa T, Murata M, Yokoo C, Tamai M, Hanada K, Katunuma N. FEBS Lett. 1991 Mar 25;280(2):311-5.

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent - Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent

Gillet L, Roger S, Besson P, Lecaille F, Gore J, Bougnoux P, Lalmanach G, Le Guennec JY. J Biol Chem. 2009 Mar 27;284(13):8680-91.

Cathepsin B inhibition limits bone metastasis in breast cancer. - Cathepsin B inhibition limits bone metastasis in breast cancer.

Withana NP, Blum G, Sameni M, Slaney C, Anbalagan A, Olive MB, Bidwell BN, Edgington L, Wang L, Moin K, Sloane BF, Anderson RL, Bogyo MS, Parker BS. Cancer Res. 2012 Mar 1;72(5):1199-209.